Exercise factors as potential mediators of cognitive rehabilitation following traumatic brain injury

To summarize what is known about how exercise mediates cognitive rehabilitation post traumatic brain injury (TBI).

TBI is a devastating condition that leads to cognitive, motor and social deficits with significant social and economic burdens. Physical exercise has been shown to mediate cognitive rehabilitation post-TBI. The therapeutic effects of exercise are related in part to its ability to increase brain-derived neurotrophic factor (Bdnf) expression in the hippocampus. However, we have only recently begun to understand how exercise induces Bdnf expression in the brain through the identification of peripheral exercise factors. In this review, we will discuss the literature describing the various known exercise factors and we will assess their potential role in TBI.

The reviewed literature makes a strong case that exercise has important protective roles post-TBI. It also highlights the relevance and role of peripheral exercise factors, such as lactate and beta-hydroxybutyrate in mediating beneficial effects of exercise on cognition. Studying exercise factors in the context of injury will likely contribute to better therapeutic strategies for TBI.