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Related Concept Videos

Disorders of the Autonomic Nervous System01:18

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Updated: Jan 18, 2026

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
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Autonomic dysfunction following mild traumatic brain injury.

Cali C M Callaway1, Barry E Kosofsky2,1

  • 1Weill Cornell Medical College, New York City, New York, USA.

Current Opinion in Neurology
|October 1, 2019
PubMed
Summary
This summary is machine-generated.

Mild traumatic brain injuries (mTBI), or concussions, often involve autonomic nervous system (ANS) dysfunction. Graded exercise programs can improve ANS function and symptoms, offering a new treatment approach for concussion recovery.

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Area of Science:

  • Neurology
  • Sports Medicine
  • Physiology

Background:

  • Millions of concussions (mild traumatic brain injuries, mTBI) occur annually, with many unreported.
  • Current diagnostic tools lack objectivity, and evidence-based treatments are limited for concussed individuals.

Purpose of the Study:

  • To review recent research on mild traumatic brain injury (mTBI) and its connection to the autonomic nervous system (ANS).
  • To explore the potential of ANS biomarkers for diagnosing and monitoring concussion recovery.
  • To evaluate exercise as a treatment for concussion and its impact on ANS function.

Main Methods:

  • Review of current scientific literature on mTBI, ANS function, and exercise interventions.
  • Analysis of studies investigating ANS dysfunction following mTBI.
  • Examination of research on the efficacy of graded exercise programs in concussion management.

Main Results:

  • Autonomic nervous system (ANS) dysfunction is frequently observed after mTBI and contributes to common concussion symptoms.
  • ANS dysfunction following mTBI may be linked to diffuse axonal injury affecting brainstem structures.
  • Graded exercise programs initiated within the first week of concussion improve ANS function and patient symptoms, contrary to previous beliefs.

Conclusions:

  • Autonomic nervous system (ANS) dysfunction plays a significant role in concussion symptomatology and recovery.
  • Objective biomarkers related to ANS function can aid in mTBI diagnosis and monitoring.
  • Exercise is a well-tolerated and effective treatment for acute concussion and postconcussion syndrome (PCS), enhancing ANS function.