Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

936
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
936
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.1K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.1K
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

543
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
543
Drug Dependence01:17

Drug Dependence

1.6K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.6K
Drug Therapy01:28

Drug Therapy

246
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
246

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outpatient Direct Initiation of Injectable Buprenorphine in a Harm Reduction Agency and Primary Care Clinic: A Retrospective Case Series.

Journal of addiction medicine·2026
Same author

The Association Between Race and Complications in Free Flap Surgery of the Head and Neck.

Cureus·2026
Same author

Patellofemoral joint forces during running are not different between adolescents with and without patellofemoral pain-a cross-sectional study.

Frontiers in sports and active living·2026
Same author

Older Age Is Associated With Long-Term Retention in Buprenorphine Treatment for Opioid Use Disorder.

Journal of the American Geriatrics Society·2026
Same author

Impact of Medication for Opioid Use Disorder on Patient Directed Discharge Among Patients with Opioid Use Disorder.

Journal of general internal medicine·2026
Same author

Implementation Outcomes of Low Threshold Care for Persons with Opioid Use Disorders.

Journal of general internal medicine·2026

Related Experiment Video

Updated: Jan 18, 2026

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

848

Defining Low-threshold Buprenorphine Treatment.

Andrea Jakubowski1, Aaron Fox

  • 1Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, NY (AJ, AF).

Journal of Addiction Medicine
|October 1, 2019
PubMed
Summary

Low-threshold buprenorphine treatment removes barriers for opioid use disorder (OUD) care. This approach increases access by offering same-day entry, flexibility, and harm reduction in accessible locations.

More Related Videos

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

2.9K
A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
10:35

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

11.6K

Related Experiment Videos

Last Updated: Jan 18, 2026

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

848
A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

2.9K
A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
10:35

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

11.6K

Area of Science:

  • Addiction Medicine
  • Public Health
  • Pharmacology

Background:

  • Buprenorphine is a safe and effective medication for opioid use disorder (OUD).
  • Current treatment programs often have restrictive entry and continuation requirements, limiting access.
  • A significant gap exists between the need for OUD treatment and the number of Americans receiving it.

Purpose of the Study:

  • To define the essential features of "low-threshold treatment" for OUD.
  • To propose guiding principles for implementing low-threshold buprenorphine treatment.
  • To review the evidence and rationale supporting these principles.

Main Methods:

  • Literature review and synthesis of existing evidence on OUD treatment barriers.
  • Conceptualization and definition of low-threshold treatment principles.
  • Discussion of implementation strategies and future research directions.

Main Results:

  • Low-threshold treatment aims to minimize barriers to accessing buprenorphine for OUD.
  • Key principles include same-day treatment entry, a harm-reduction approach, flexibility, and wide availability.
  • These principles are supported by evidence and rationale for improving OUD care delivery.

Conclusions:

  • Implementing low-threshold buprenorphine treatment can significantly expand access to care for OUD.
  • The proposed principles provide a framework for developing more accessible and effective treatment programs.
  • Further research is needed to optimize and evaluate low-threshold models in diverse settings.