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Lipid profile differences during menopause: a review with meta-analysis.
Ananthan Ambikairajah1, Erin Walsh, Nicolas Cherbuin
1Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, Australian National University, Canberra, Australia.
Postmenopausal women have significantly higher lipid levels, including triglycerides and cholesterol, compared to premenopausal women. These changes contribute to an increased risk of cardiovascular disease.
Area of Science:
- Endocrinology
- Cardiovascular Health
- Women's Health
Background:
- Menopause is associated with significant physiological changes.
- Lipid profiles are critical indicators of cardiovascular risk.
- Understanding menopausal lipid changes is vital for preventative healthcare.
Purpose of the Study:
- To quantify lipid profile differences between premenopausal and postmenopausal women.
- To provide precise estimates of these lipid variations.
Main Methods:
- A meta-analytic approach was employed.
- Data from 66 studies involving 114,655 women were synthesized.
- Participants were categorized into premenopausal and postmenopausal groups.
Main Results:
- Postmenopausal women exhibited significantly higher levels of triglycerides, total cholesterol, low-density lipoprotein, and total cholesterol to high-density lipoprotein ratio.
- No significant difference in high-density lipoprotein levels was observed between the groups.
- Age differences partially explained the observed lipid variations.
Conclusions:
- The findings highlight an unfavorable lipid profile in postmenopausal women.
- This altered profile increases the risk of cardiovascular diseases like heart disease and stroke.
- Timely lifestyle or pharmacological interventions are crucial to mitigate these risks.
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