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Updated: Jan 18, 2026

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
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Efficacy of Single- Versus Split-dose Polyethylene Glycol for Colonic Preparation in Children: A Randomized Control

Parijat Ram Tripathi1, Ujjal Poddar, Surender Kumar Yachha

  • 1Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Journal of Pediatric Gastroenterology and Nutrition
|October 1, 2019
PubMed

Insights

Split-dose polyethylene glycol (PEG) is more effective for pediatric bowel preparation than single-dose regimens. This method offers better tolerability and improved sleep quality in children undergoing colonoscopy.

Area of Science:

  • Gastroenterology
  • Pediatric Endoscopy
  • Pharmacology

Background:

  • Polyethylene glycol (PEG) is a primary agent for colon cleansing, but its large volume can cause adverse effects.
  • While split-dose PEG is common in adults, its use in pediatric populations lacks comparative studies.

Purpose of the Study:

  • To compare the efficacy and tolerability of split-dose versus single-dose PEG for bowel preparation in children.
  • To evaluate the impact on patient comfort and sleep quality.

Main Methods:

  • A randomized trial involving children aged 1-18 years comparing single-dose and split-dose PEG regimens.
  • Bowel preparation effectiveness assessed using the Aronchik scale by a blinded endoscopist.
  • Interobserver variability analyzed by comparing with a blinded endoscopy nurse's scoring.

Main Results:

  • Split-dose PEG demonstrated superior efficacy (76.34% satisfactory preparation vs. 43.02% for single-dose, P < 0.001).
  • Adverse effects like nausea, vomiting, and sleep disturbance were significantly reduced with split-dose PEG (P < 0.05).
  • Patients receiving split-dose PEG consumed the solution faster and experienced better sleep quality.

Conclusions:

  • Split-dose PEG is a more effective and better-tolerated bowel preparation method for pediatric colonoscopy.
  • This regimen improves patient comfort and sleep quality in the pediatric population.
  • The findings support the use of split-dose PEG for children requiring colon cleansing.
Abstract

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