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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Relationship between corneal deformation amplitude and optic nerve head structure in primary open-angle glaucoma
Younhea Jung1, Hae-Young Lopilly Park2, Chan Kee Park2
1Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine.
Medicine
|October 1, 2019
Summary
Corneal deformation amplitude (DA) is linked to optic nerve head structure in primary open-angle glaucoma (POAG). Lower DA correlates with deeper lamina cribrosa and cup, and larger parapapillary atrophy in POAG patients.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Corneal Biomechanics
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Optic nerve head (ONH) parameters are crucial for diagnosing and monitoring glaucoma.
- Corneal properties may influence intraocular pressure measurements and glaucoma risk.
Purpose of the Study:
- To investigate the relationship between corneal deformation amplitude (DA) and ONH parameters in POAG patients.
- To determine if corneal biomechanics correlate with structural changes at the optic nerve head.
Main Methods:
- Observational study including 58 POAG patients.
- Corneal deformation amplitude measured using Corvis Scheimpflug Technology (ST).
- Optic nerve head imaging obtained via color optic disc photography, Heidelberg Spectralis OCT, Cirrus OCT, and Heidelberg Retina Tomograph (HRT).
- Pearson correlation analysis performed, adjusting for age, intraocular pressure, central corneal thickness, and axial length.
Main Results:
- Corneal DA showed a negative association with lamina cribrosa (LC) depth (r=-0.390, P=.003) after confounder adjustment.
- A positive relationship was observed between corneal DA and parapapillary atrophy (PPA) area (r=0.321, P=.046).
- Corneal DA was negatively correlated with cup volume (r=-0.351, P=.017) and mean cup depth (r=-0.409, P=.005) measured by HRT.
Conclusions:
- Corneal DA is significantly related to key optic nerve head parameters in POAG.
- Lower corneal DA in POAG patients is associated with greater LC depth, deeper cups, and smaller PPA.
- These findings suggest corneal biomechanics may play a role in glaucoma pathophysiology and structural changes.
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