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Predicting Development of Bilateral Menière's Disease Based on cVEMP Threshold and Tuning
Kimberley S Noij1, Barbara S Herrmann2,3, John J Guinan2,4
1Department of Otolaryngology, Massachusetts Eye and Ear.
Objective:
To investigate if the cervical vestibular evoked myogenic potential (cVEMP) is predictive for developing bilateral Menière's disease (MD).
Study Design:
Retrospective cohort study.
Setting:
Tertiary care center.
Patients:
Records of 71 patients previously diagnosed with unilateral MD at our institution who underwent cVEMP testing between 2002 and 2011 were screened.
Intervention:
Patients were contacted to answer a questionnaire to identify which patients had developed bilateral disease. Based on questionnaires and medical charts, 49 patients with a follow-up time of at least 5 years were included. The 49 originally asymptomatic ears are referred to as "study ears." Previously reported cVEMP criteria (original criteria) applied to study-ear cVEMPs separated them into Menière-like and normal-like groups.
Main Outcome Measure:
The main purpose was to determine if previously obtained cVEMP thresholds and tuning ratios of unilateral MD patients could predict who develops bilateral disease.
Results:
From the 49 included patients, 12 developed bilateral disease (24.5%). The study ears characterized by original cVEMP criteria as Menière-like were significantly more likely to develop bilateral disease compared with the normal-like study ears. The original criteria predicted development of bilateral disease with a positive predictive value (PPV) and negative predictive value (NPV) of 58.3% and 86.5% respectively. ROC curves were used to revise cVEMP criteria for predicting the progression to bilateral disease. A revised criterion combining three cVEMP metrics, reached a PPV and NPV of 85.7% and 93.7%.
Conclusion:
cVEMP threshold and tuning in unilateral MD patients are predictive of which patients will develop bilateral disease.
