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Updated: Jan 18, 2026

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
Understanding the patient population and test utilization for hepatitis B virus testing
Rihwa Choi1,2, Yejin Oh1, Seungman Park1
1Department of Laboratory Medicine, Green Cross Laboratories, Gyeonggi-do, Korea.
This study analyzed Hepatitis B virus (HBV) serologic and virologic tests in Korean adults. While HBV DNA and hepatitis B envelope antigen (HBeAg) showed correlation, over half of samples lacked agreement between these key indicators.
Area of Science:
- Hepatology
- Clinical Virology
- Laboratory Medicine
Background:
- Hepatitis B virus (HBV) infection presents diverse global epidemiologies influenced by migration, vaccination, and treatment advancements.
- Understanding patient population characteristics and test utilization is crucial for evaluating laboratory test performance and enhancing clinical laboratory quality.
Purpose of the Study:
- To evaluate the characteristics of a Korean adult patient population exposed to HBV.
- To assess the utilization and clinical performance of serologic and virologic laboratory tests for HBV.
Main Methods:
- Analysis of 22,750 specimens from 17,523 adult Korean patients over one year.
- Evaluation of five serologic and virologic tests: hepatitis B surface antigen, hepatitis B surface antibody, hepatitis B envelope antigen (HBeAg), hepatitis B envelope antibody, and HBV DNA.
- Assessment of test prevalence and correlation between HBV DNA and HBeAg.
Main Results:
- A total of 1340 specimens from 1172 patients underwent evaluation of five key HBV serologic and virologic tests.
- A strong correlation (ρ = 0.85, P < .0001) was observed between HBV DNA and HBeAg.
- A significant discordance was found, with 51.9% of samples showing a lack of agreement between HBV DNA and HBeAg test results.
Conclusions:
- Analyzing the prevalence of patients across five serologic and virologic laboratory results enhances understanding of patient demographics.
- Improved knowledge of patient characteristics and test results can lead to better test utilization and clinical laboratory practices.
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