Platelet-rich plasma treatment for melasma: A pilot study

Area of Science:

• Dermatology
• Regenerative Medicine

Background:

• Melasma treatments often have limited success and potential complications.
• Exploring novel therapeutic options for melasma is crucial.

Purpose of the Study:

• To evaluate the efficacy of platelet-rich plasma (PRP) injections for treating melasma.
• To compare PRP treatment against a placebo in a randomized, split-face trial.

Main Methods:

• A randomized, split-face, single-blinded trial involved ten female patients with melasma.
• Platelet-rich plasma (PRP) was intradermally injected on one side, with normal saline on the other, over four sessions.
• Outcomes were assessed using modified Melasma Area and Severity Index (mMASI), Mexameter®, and Antera® 3D, alongside patient satisfaction.

Main Results:

• Significant improvement in mMASI scores and Antera® 3D-assessed melanin levels was observed in the PRP group compared to the control.
• Patient satisfaction significantly increased over the treatment period.
• Mexameter® results showed no significant difference, though a trend towards reduced pigmentation was noted with PRP; side effects were mild and transient.

Conclusions:

• Intradermal PRP injection demonstrated significant efficacy in improving melasma within six weeks, based on mMASI scores and melanin levels.
• PRP treatment led to increased patient satisfaction and had a favorable safety profile.
• PRP injection presents a promising alternative or adjuvant therapy for melasma, warranting further investigation into its long-term effects.