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Resting-state functional magnetic resonance imaging versus task-based activity for language mapping and correlation
Jean-Michel Lemée1,2, David Hassanein Berro3, Florian Bernard1,4
1Department of Neurosurgery, University Hospital of Angers, Angers, France.
Brain and Behavior
|October 1, 2019
Summary
Resting-state fMRI (rsfMRI) offers higher sensitivity for preoperative language mapping than task-based fMRI. This method identifies crucial brain language areas with 100% sensitivity, aiding surgical planning for brain lesions.
Area of Science:
- Neuroimaging
- Neurosurgery
- Cognitive Neuroscience
Background:
- Preoperative language mapping is crucial for resectable brain lesions.
- Functional magnetic resonance imaging (fMRI) uses blood-oxygen-level-dependent (BOLD) signals.
- Task-based fMRI requires patient cooperation, while resting-state fMRI (rsfMRI) analyzes spontaneous BOLD signal synchronicity.
Purpose of the Study:
- To compare the efficacy of rsfMRI and task-based fMRI for preoperative language mapping.
- To evaluate these fMRI techniques against intraoperative cortical mapping (CM).
Main Methods:
- Fifty adult patients undergoing surgery for brain lesions were included.
- All patients underwent presurgical language mapping using both task fMRI and rsfMRI.
- Language networks identified by fMRI were compared to those found during intraoperative CM via electric cortical stimulation.
Main Results:
- rsfMRI demonstrated 100% sensitivity in detecting language areas during CM.
- Task-based fMRI showed a sensitivity of 65.6%.
- Task fMRI identified semantic network nodes, while rsfMRI identified main semantic areas.
Conclusions:
- rsfMRI is a sensitive tool for presurgical language mapping, outperforming task-based fMRI.
- While rsfMRI requires precautions and may have lower specificity, it simplifies functional network identification.
- Further research is needed to fully assess rsfMRI's sensitivity, specificity, and clinical utility compared to task-based fMRI.
