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Related Experiment Videos

Is there increased WAIS pattern variability in Huntington's disease?

M E Strauss, J Brandt

    Journal of Clinical and Experimental Neuropsychology
    |February 1, 1985
    PubMed
    Summary

    Individuals at risk for Huntington's Disease do not show decreased WAIS subtest intercorrelations. New data contradict previous findings suggesting greater variability in at-risk individuals.

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    Area of Science:

    • Neuropsychology
    • Genetics
    • Psychometrics

    Background:

    • Previous research suggested individuals at risk for Huntington's Disease exhibit altered cognitive profiles on the WAIS.
    • Specifically, Josiassen et al. (1982) proposed greater variability and reduced subtest intercorrelations in at-risk individuals.

    Purpose of the Study:

    • To re-examine the conclusion that individuals at risk for Huntington's Disease display attenuated WAIS subtest intercorrelations.
    • To present new data that challenge the findings of Josiassen et al. (1982).

    Main Methods:

    • Re-analysis of previously reported data.
    • Collection and analysis of new psychometric data from at-risk subjects.
    • Examination of methodological considerations in the original study.

    Main Results:

    • The re-examination suggests the original conclusion regarding attenuated WAIS subtest intercorrelations is not supported.
    • New data collected are inconsistent with the hypothesis of reduced subtest intercorrelations in individuals at risk for Huntington's Disease.

    Conclusions:

    • The previously reported finding of attenuated WAIS subtest intercorrelations in at-risk Huntington's Disease subjects is not warranted.
    • New evidence indicates that cognitive variability, as measured by WAIS subtest intercorrelations, does not differ in at-risk individuals.

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