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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

795
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
795

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Predicting Skin Barrier Dysfunction and Atopic Dermatitis in Early Infancy.

Eva Maria Rehbinder1, Kim M Advocaat Endre1, Karin C Lødrup Carlsen2

  • 1Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Dermatology, Oslo University Hospital, Oslo, Norway.

The Journal of Allergy and Clinical Immunology. in Practice
|October 1, 2019
PubMed
Summary

Dry skin in infants can predict atopic dermatitis (AD) later in childhood. Specific parental and pregnancy factors also influence dry skin, high transepidermal water loss (TEWL), and AD development.

Keywords:
Allergic diseasesAtopic dermatitisAtopyDry skinEczemaPreventADALLSkin barrierTEWLXerosis

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Area of Science:

  • Dermatology
  • Pediatrics
  • Allergology

Background:

  • Dry skin is linked to increased transepidermal water loss (TEWL), a precursor to childhood atopic dermatitis (AD).
  • Identifying early predictors is crucial for understanding AD development.

Purpose of the Study:

  • To identify parental, prenatal, and perinatal factors predicting dry skin, high TEWL, and AD at 3 months.
  • To assess if dry skin or high TEWL at 3 months predicts AD at 6 months.

Main Methods:

  • Prospective birth cohort study of 1150 mother-child pairs.
  • Assessed dry skin, TEWL, and eczema (as AD proxy) at 3 and 6 months.
  • Collected predictive factor data via questionnaires and obstetric charts.

Main Results:

  • Paternal age >37 and delivery after 38 weeks predicted dry skin.
  • Male sex, winter birth, and maternal allergy predicted high TEWL.
  • Elective C-section, multiparity, and maternal allergy predicted eczema.
  • Dry skin at 3 months predicted eczema at 6 months (aOR 1.92).

Conclusions:

  • Parental and pregnancy factors influence early infant skin conditions and AD risk.
  • Infant dry skin at 3 months is a significant predictor of AD development by 6 months.