Apparent supersensitivity of platelet 5-HT receptors in lithium-treated patients

An increased 5-HT-induced platelet aggregatory response was seen in bipolar and unipolar patients who were being treated with lithium prophylactically. The responses were not related to the patients' lithium levels or affective morbidity. The results are discussed with reference to the action of antidepressive treatments on 5-HT receptor systems in the platelet and the CNS.