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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Association of Kidney Function Tests with a Cardio-Ankle Vascular Index in Community-Dwelling Individuals with a

Javad Alizargar1, Chyi-Huey Bai2, Nan-Chen Hsieh3

  • 1Research Center For Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan. jaz.tmu@gmail.com.

Medicina (Kaunas, Lithuania)
|October 2, 2019
PubMed

Insights

Estimated glomerular filtration rate (eGFR) is an independent predictor of arterial stiffness, even with normal or slightly decreased kidney function. This finding aids in assessing cardiovascular disease risk in community populations.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a known cardiovascular disease (CVD) risk factor.
  • Previous research on CKD's role in atherosclerosis has yielded conflicting results.
  • Arterial stiffness is a key indicator of cardiovascular risk.

Purpose of the Study:

  • To investigate if estimated glomerular filtration rate (eGFR) and renal function tests independently predict arterial stiffness.
  • Focus on community-dwelling individuals with normal (eGFR ≥90) or slightly decreased (eGFR 60-90) kidney function.

Main Methods:

  • Analysis of data from 164 community-dwelling individuals.
  • Collected demographic information, medical history, atherosclerosis risk factors, laboratory tests, eGFR, and urine albumin creatinine ratio (UACR).
  • Utilized multiple linear regression to assess independence of eGFR and arterial stiffness (CAVI).

Main Results:

  • Significant differences in age, systolic blood pressure (SBP), hypertension (HTN), and cardio-ankle vascular index (CAVI) were observed between normal and slightly decreased eGFR groups.
  • Blood urea nitrogen (BUN), glycated hemoglobin (HbA1c), and eGFR differed between high- and low-CAVI groups and correlated with CAVI.
  • eGFR demonstrated an independent association with CAVI, irrespective of other atherosclerosis risk factors.

Conclusions:

  • eGFR is an independent factor associated with arterial stiffness in individuals with normal or mildly reduced kidney function.
  • A predictive model for arterial stiffness can incorporate eGFR, HTN, BMI, and SBP for community-dwelling populations.

Keywords:
ankle brachial indexatherosclerosiscardio-ankle vascular indexcardiovascular diseaseglomerular filtration ratehypertension

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