Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

13.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.0K
Longitudinal Studies01:26

Longitudinal Studies

441
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
441
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.2K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.2K
Telomeres and Telomerase02:41

Telomeres and Telomerase

26.7K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
26.7K
Replication in Eukaryotes01:29

Replication in Eukaryotes

16.9K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
16.9K
Truncation in Survival Analysis01:09

Truncation in Survival Analysis

542
Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
542

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypophosphatemia-factors associated with its development and 90-day mortality effect: a prospective observational study.

Frontiers in medicine·2026
Same author

Piezoelectricity from Dopant-Induced Structural Distortions in Molecular Crystals Revealed by Raman Spectroscopy.

Journal of the American Chemical Society·2026
Same author

Smart feeding: the role of artificial intelligence and integrated nutrition platforms in the ICU.

Current opinion in critical care·2026
Same author

Chronic Lymphocytic Leukemia (CLL)-Derived Extracellular Vesicles (EVs) Modulate Monocytes to Become CLL-Supportive Cells.

International journal of molecular sciences·2026
Same author

Artificial intelligence in nutritional assessment and decision making.

Current opinion in clinical nutrition and metabolic care·2026
Same author

Electrolyte imbalance and post-open-heart surgery complications: Is there a link?

Journal of intensive medicine·2026

Related Experiment Video

Updated: Jan 6, 2026

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

2.8K

Telomere Length Changes during Critical Illness: A Prospective, Observational Study.

Benjamin Zribi1, Orit Uziel2, Meir Lahav3

  • 1Department of Anesthesiology, Rabin Medical Center, Campus Beilinson, Petah Tikva 49100, Israel. benjzr@gmail.com.

Genes
|October 2, 2019
PubMed
Summary

Telomere length changes, including shortening and lengthening, occur in acutely ill patients. Younger patients showed more telomere shortening, which correlated with white blood cell count changes, but no clear outcome associations were found.

Keywords:
acute illnessintensive caresepsistelomereswhite blood cells

More Related Videos

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.2K
Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

3.6K

Related Experiment Videos

Last Updated: Jan 6, 2026

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

2.8K
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.2K
Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

3.6K

Area of Science:

  • Molecular Biology
  • Critical Care Medicine
  • Gerontology

Background:

  • Telomeres, protective caps on chromosomes, shorten with age and cellular stress.
  • Understanding telomere dynamics in critical illness is crucial for assessing cellular aging and patient outcomes.

Purpose of the Study:

  • To evaluate changes in telomere length in adult patients experiencing acute illness.
  • To investigate potential correlations between telomere length dynamics and patient demographics, clinical factors, and outcomes in the intensive care unit (ICU).

Main Methods:

  • Prospective observational study involving 40 acutely ill adult patients admitted to the ICU.
  • Telomere length was assessed using a polymerase chain reaction (PCR)-based technique on blood samples collected on days 1 and 7 of ICU stay.
  • Demographic data, laboratory values (including white blood cell count), and clinical outcomes were recorded.

Main Results:

  • Telomere shortening was observed in 21 patients, lengthening in 11, and no significant change in 8.
  • Patients with telomere shortening were significantly younger than those with lengthening (45.4 vs. 61.5 years).
  • Telomere length changes correlated significantly with changes in white blood cell count; a trend towards shortening was noted in sepsis patients.

Conclusions:

  • Telomere length exhibits dynamic changes (shortening and lengthening) in acutely ill patients.
  • These changes were associated with patient age and white blood cell count but not with overall clinical outcomes.
  • Further research in more specific patient groups is needed to clarify the role of telomere dynamics in critical illness.