Adsorptive therapy as a modificator for tumor-host interaction

Area of Science:

• Oncology
• Biomedical Engineering
• Toxicology

Background:

• Paraneoplastic syndrome (PNS) and systemic toxicity complicate cancer treatment.
• New generation carbon adsorbents offer potential for enterosorption (ES).

Purpose of the Study:

• To evaluate the efficacy of ES in managing PNS and treatment-related toxicities.
• To assess the impact of ES on tumor progression and organ function.

Main Methods:

• ES was administered to mice with Lewis lung carcinoma and rats with Guerin carcinoma.
• Effects on metastasis, anemia, bone marrow activity, organ histology, and blood markers were analyzed.
• ES was also tested in rats undergoing X-ray irradiation.

Main Results:

• ES significantly suppressed metastasis and corrected anemia in mice.
• ES improved kidney and liver function, reduced oxidative stress, and decreased endogenous intoxication.
• ES demonstrated nephroprotective effects against cisplatin toxicity and aided white blood cell restoration after irradiation.

Conclusions:

• Enterosorption with advanced carbon adsorbents shows significant potential in managing paraneoplastic syndrome and reducing chemo/radiotherapy toxicity.
• ES offers a promising adjunctive therapy for cancer patients, supporting organ function and immune recovery.