Programmed necrosis and its role in management of breast cancer
Banita Thakur1, Yashwant Kumar2, Alka Bhatia1
1Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Abstract:
Breast cancer is one of the major causes of cancer related deaths in women worldwide. A major factor responsible for treatment failure in breast cancer is the development of resistance to commonly used chemotherapeutic drugs leading to disease relapse. Several studies have shown dysregulation of molecular machinery of apoptosis, the major programmed cell death pathway in breast malignancies. Thus, there is an unmet need to search for an alternative cell death pathway which can work when apoptosis is compromised. Necroptosis or programmed necrosis is a relatively recently described entity which has attracted attention in this context. Classically, even in physiological conditions necroptosis is found to act if apoptosis is not functional due to some reason. Recently, more and more studies are being conducted in different malignancies to explore the possibility and utility of inducing cell death by necroptosis. The present review describes the key molecular players involved in necroptotic pathway and their status in breast cancer. In addition, the research done to utilize this pathway for treatment of breast cancer has also been highlighted.
Insights
Breast cancer treatment failure often stems from drug resistance, impacting apoptosis. This review explores necroptosis (programmed necrosis) as a promising alternative cell death strategy for overcoming resistance in breast cancer therapy.
Area of Science:
- Oncology
- Molecular Biology
- Cell Death Pathways
Background:
- Breast cancer is a leading cause of cancer deaths in women globally.
- Treatment failure due to drug resistance and disease relapse is a significant challenge.
- Dysregulation of apoptosis, a key programmed cell death pathway, is common in breast malignancies.
Purpose of the Study:
- To review the molecular mechanisms of necroptosis.
- To examine the role and status of necroptosis in breast cancer.
- To highlight research on utilizing necroptosis for breast cancer treatment.
Main Methods:
- Literature review of molecular players in necroptosis.
- Analysis of necroptosis pathway status in breast cancer.
- Survey of therapeutic strategies targeting necroptosis in breast cancer.
Main Results:
- Necroptosis is an alternative programmed cell death pathway.
- This pathway can be activated when apoptosis is compromised.
- Key molecular components of necroptosis are relevant to breast cancer.
Conclusions:
- Necroptosis presents a potential therapeutic avenue for breast cancer.
- Targeting necroptosis may overcome chemoresistance and improve treatment outcomes.
- Further research is warranted to fully exploit necroptosis in clinical settings.
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