Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K
Overview of Exosomes01:36

Overview of Exosomes

3.4K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.4K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.1K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.1K
Exocytosis00:51

Exocytosis

72.9K
Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
72.9K
Exocytosis00:50

Exocytosis

8.9K
Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...
8.9K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

9.3K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meta-amplified dark-field interferometric scattering microscopy.

Nature communications·2026
Same author

Mode-Specific Coherent Interference of Vibrational Sum-Frequency Generation Imaging: An Approach to Differentiate Lung Tumors through Collagen Interfibrillar Distances.

Journal of the American Chemical Society·2025
Same author

Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis.

Nature communications·2024
Same author

Colocalization of protein and microRNA markers reveals unique extracellular vesicle subpopulations for early cancer detection.

Science advances·2024
Same author

Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis.

Cancer research communications·2024
Same author

Cancer-cell-secreted extracellular vesicles target p53 to impair mitochondrial function in muscle.

EMBO reports·2023

Related Experiment Video

Updated: Jan 6, 2026

Extraction of Extracellular Vesicles from Whole Tissue
09:03

Extraction of Extracellular Vesicles from Whole Tissue

Published on: February 7, 2019

15.9K

Extracellular Vesicles and Metastasis.

Shizhen Emily Wang1

  • 1Department of Pathology, University of California San Diego, La Jolla, California 92093, USA.

Cold Spring Harbor Perspectives in Medicine
|October 2, 2019
PubMed
Summary
This summary is machine-generated.

Cancer cells release distinct extracellular vesicles (EVs) that mediate intercellular communication, driving tumor progression and metastasis. Understanding these EV-driven mechanisms offers new therapeutic avenues for cancer treatment.

More Related Videos

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

10.6K
Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

9.2K

Related Experiment Videos

Last Updated: Jan 6, 2026

Extraction of Extracellular Vesicles from Whole Tissue
09:03

Extraction of Extracellular Vesicles from Whole Tissue

Published on: February 7, 2019

15.9K
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

10.6K
Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

9.2K

Area of Science:

  • Cell Biology
  • Oncology
  • Biochemistry

Background:

  • Extracellular vesicles (EVs), including exosomes and microvesicles, are fundamental to cellular communication.
  • Cancer cells exhibit altered EV secretion in quantity and composition due to intrinsic and microenvironmental factors.
  • EVs, once considered waste exporters, are now recognized as critical mediators of intercellular cargo transfer.

Purpose of the Study:

  • To elucidate the role of extracellular vesicles (EVs) in cancer progression and metastasis.
  • To highlight the impact of EV-mediated intercellular communication on tumor heterogeneity and microenvironment.
  • To explore the potential of EV-based mechanisms for novel cancer therapeutic strategies.

Main Methods:

  • Literature review of recent studies on extracellular vesicle (EV) function in cancer.
  • Analysis of EV cargo transport and its influence on cellular functions.
  • Investigation of EV roles in tumor heterogeneity, vascular remodeling, immunomodulation, and premetastatic niche formation.

Main Results:

  • Cancer cell-derived EVs significantly differ from normal cell EVs in amount and composition.
  • EVs facilitate intercellular communication within and outside the tumor microenvironment.
  • EVs play crucial roles in tumor plasticity, immune evasion, and the establishment of premetastatic niches, promoting metastasis.

Conclusions:

  • Extracellular vesicles (EVs) are key players in cancer progression and metastasis.
  • EV-mediated intercellular interactions contribute to multifaceted changes in tumor and surrounding tissues.
  • Targeting EV pathways presents a promising strategy for developing innovative cancer therapies.