Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.4K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.4K
Neuron Structure01:31

Neuron Structure

230.3K
Overview
230.3K
Neuron Structure01:30

Neuron Structure

17.6K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
17.6K
Neural Circuits01:25

Neural Circuits

2.5K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.5K
Catenins01:23

Catenins

3.0K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
3.0K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.4K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiscale characterization of the human claustrum from histology to MRI.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Neuromorphic hierarchical modular reservoirs.

Nature communications·2026
Same author

Replicability of multivariate brain-behaviour associations depends on clinical profile.

Communications biology·2026
Same author

Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study.

bioRxiv : the preprint server for biology·2026
Same author

Rethinking cortical hypertrophy in temporal lobe epilepsy.

Brain : a journal of neurology·2026
Same author

Aging and metabolism contribute separately to brain-body health.

PLoS biology·2026
Same journal

The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Superstatistics approach to turbulent circulation fluctuations.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

A molecular timescale for evolution of cobamide biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Related Experiment Video

Updated: Jan 6, 2026

Juxtasomal Biocytin Labeling to Study the Structure-function Relationship of Individual Cortical Neurons
10:36

Juxtasomal Biocytin Labeling to Study the Structure-function Relationship of Individual Cortical Neurons

Published on: February 25, 2014

14.0K

Gradients of structure-function tethering across neocortex.

Bertha Vázquez-Rodríguez1, Laura E Suárez1, Ross D Markello1

  • 1McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC H3A 2B4, Canada.

Proceedings of the National Academy of Sciences of the United States of America
|October 2, 2019
PubMed
Summary
This summary is machine-generated.

Brain structure and function are closely linked in primary areas but diverge in higher-order regions. This study reveals how white matter architecture shapes neuronal coactivation patterns across the brain.

Keywords:
connectomecortical gradientstructure–function

More Related Videos

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.3K
Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.8K

Related Experiment Videos

Last Updated: Jan 6, 2026

Juxtasomal Biocytin Labeling to Study the Structure-function Relationship of Individual Cortical Neurons
10:36

Juxtasomal Biocytin Labeling to Study the Structure-function Relationship of Individual Cortical Neurons

Published on: February 25, 2014

14.0K
Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.3K
Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.8K

Area of Science:

  • Neuroscience
  • Brain Connectivity
  • Systems Neuroscience

Background:

  • Brain white matter architecture influences neuronal coactivation patterns and functional networks.
  • Existing models struggle to fully explain the structure-function relationship in the brain.

Purpose of the Study:

  • To investigate the relationship between structural and functional connectivity profiles of individual brain areas.
  • To determine how white matter architecture relates to neuronal coactivation patterns.

Main Methods:

  • Utilized a multilinear model incorporating spatial proximity, routing, and diffusion.
  • Analyzed structure-function relationships across the neocortex.

Main Results:

  • Structure-function relationships vary significantly across the neocortex.
  • Close correspondence in unimodal, primary sensory, and motor regions.
  • Divergence in transmodal cortex, including default mode and salience networks, following functional and cytoarchitectonic hierarchies.

Conclusions:

  • Structural and functional brain networks do not align uniformly.
  • Networks gradually uncouple in higher-order polysensory areas, indicating a complex interplay between structure and function.