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Related Experiment Videos

[Vindesine in oral cancers].

H Szpirglas, M Marneur, J M Vaillant

    Presse Medicale (Paris, France : 1983)
    |February 16, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Vindesine showed efficacy in treating buccal cavity cancers. Continuous infusion proved more effective than bolus injections for advanced tumors, despite causing venous damage.

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    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • Vindesine, a vinblastine derivative, is an antineoplastic agent.
    • Malignant tumors of the buccal cavity represent a significant oncological challenge.

    Purpose of the Study:

    • To evaluate the efficacy and toxicity of vindesine in patients with untreated buccal cavity malignancies.
    • To compare different administration methods of vindesine.

    Main Methods:

    • Vindesine was administered pre-operatively in weekly intravenous courses (1-3 weeks) to 36 patients.
    • For inoperable tumors, vindesine was given prior to radiotherapy via weekly bolus injections or 5-day continuous intravenous infusion.

    Main Results:

    • Pre-operative vindesine yielded major responses in 22.2% of patients.

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  • Continuous infusion demonstrated higher efficacy (3/10 responses, including complete remission) compared to weekly bolus injections (1/18 response) in the radiotherapy group.
  • Venous damage was the primary toxicity associated with continuous infusion.

    • Conclusions:

    • Vindesine exhibits activity against buccal cavity tumors.
    • Continuous intravenous infusion of vindesine is a more effective administration method than bolus injections for advanced disease.
    • Careful monitoring for venous complications is essential during continuous infusion therapy.