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Motoric cognitive risk syndrome and incident dementia: results from a population-based prospective and observational
O Beauchet1,2,3,4, H Sekhon1,3,5, C P Launay6
1Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada.
Background And Purpose:
Motoric cognitive risk syndrome (MCR), which is the juncture of subjective cognitive complaint and slow gait speed, is a pre-dementia stage. The aims of the study are (i) to compare characteristics between individuals who have MCR defined using slow walking speed and/or increased five-times-sit-to-stand (FTSS) time as its motor component(s); and (ii) to characterize the association of MCR and its various motor components with incident dementia including Alzheimer disease and non-Alzheimer dementia in the participants of the Epidémiologie de l'Ostéoporose (EPIDOS) study.
Methods:
This prospective and observational cohort study selected 651 participants recruited from the EPIDOS study in Toulouse (France). MCR was defined as the association of subjective cognitive complaint and slow gait speed and/or increased FTSS time in participants without either dementia and mobility disabilities at baseline. Individuals with dementia were prospectively diagnosed during the physical and neuropsychological assessments included in the 7-year follow-up.
Results:
The prevalence of MCR was around 7% when using an exclusive motor criterion, either slow gait speed or increased FTSS time, and was 20.9% when MCR subgroups were pooled. MCR was positively associated with incident dementia regardless of its type, and with Alzheimer disease in the slow gait speed MCR subgroup [odds ratio (OR) > 2.18 with P ≤ 0.037] but not with non-Alzheimer dementia. No significant association between incident dementia and MCR defined using increased FTSS time was shown.
Conclusions:
Our findings confirm that MCR is associated with incident dementia and that slow gait speed is the appropriate motor criterion for detecting dementia risk.
Insights
Motoric cognitive risk syndrome (MCR) predicts dementia. Slow gait speed, a key MCR component, is linked to increased dementia risk, including Alzheimer's disease.
Area of Science:
- Neurology
- Gerontology
- Epidemiology
Background:
- Motoric cognitive risk syndrome (MCR) represents a pre-dementia stage.
- MCR is characterized by subjective cognitive complaints and impaired motor function.
Purpose of the Study:
- To compare characteristics of individuals with MCR using different motor components (gait speed, sit-to-stand time).
- To assess the association of MCR and its components with incident dementia, including Alzheimer's disease.
Main Methods:
- Prospective observational cohort study of 651 participants from the EPIDOS study.
- MCR defined by subjective cognitive complaints plus slow gait speed and/or increased five-times-sit-to-stand (FTSS) time.
- 7-year follow-up for dementia diagnosis.
Main Results:
- MCR prevalence was 7% (exclusive motor criterion) and 20.9% (pooled subgroups).
- MCR positively associated with all incident dementia types.
- Slow gait speed MCR subgroup showed significant association with Alzheimer's disease (OR > 2.18).
- No significant association found for MCR defined by increased FTSS time.
Conclusions:
- MCR is confirmed as a predictor of incident dementia.
- Slow gait speed is identified as the most appropriate motor criterion for dementia risk detection.
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