Monocyte/lymphocyte ratio is associated with carotid stenosis in ischemic stroke: A retrospective analysis
Bo Zuo1, Sha Zhu2,3, Xue Meng2
1Department of Cardiology, Cardiovascular Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Insights
The monocyte/lymphocyte ratio (MLR) is linked to severe carotid artery stenosis in ischemic stroke patients. This ratio may serve as a diagnostic marker for carotid stenosis severity.
Area of Science:
- Vascular Medicine
- Neurology
- Hematology
Background:
- Carotid artery stenosis, often due to atherosclerosis, is a significant risk factor for ischemic stroke.
- Understanding predictors of stroke severity is crucial for patient management.
Purpose of the Study:
- To investigate the association between monocyte/lymphocyte ratio (MLR) and carotid stenosis severity in ischemic stroke patients.
- To determine if MLR is an independent risk factor for carotid stenosis.
Main Methods:
- Retrospective analysis of 395 ischemic stroke patients.
- Carotid stenosis severity assessed via ultrasound.
- Multivariate logistic regression and ROC curve analysis employed.
Main Results:
- A significant correlation was observed between MLR and carotid stenosis severity.
- MLR emerged as an independent risk factor for carotid stenosis (OR: 9.74).
- MLR cutoff of 0.20 showed 80.40% sensitivity and 26.40% specificity for predicting stenosis severity.
Conclusions:
- Monocyte/lymphocyte ratio is an independent risk factor for carotid stenosis severity in ischemic stroke patients.
- MLR may be a valuable index for diagnosing carotid stenosis severity.
Background:
Carotid artery stenosis, mainly caused by carotid atherosclerosis, is related to ischemic stroke. This study was to investigate whether monocyte/lymphocyte ratio (MLR) was associated with increased severity of carotid stenosis in patients with ischemic stroke.
Methods:
A total of 395 participants with ischemic stroke were retrospectively analyzed. The severity of carotid stenosis was evaluated by ultrasound examination. Patients were divided into two groups: nonsevere stenosis group and severe stenosis group. Multivariate logistic analysis was used to evaluate risk factors.
Results:
A significant correlation was found between MLR and the severity of carotid stenosis in patients with ischemic stroke. MLR was the independent risk factor of carotid stenosis (OR: 9.74, 95% CI: 1.16-81.54). In the ROC curves analysis, a cutoff value of 0.20 for MLR predicted the severity of carotid stenosis with a sensitivity of 80.40% and specificity of 26.40% (ROC area under the curve: 0.598, 95% CI: 0.53-0.67, p = .004).
Conclusion:
Monocyte/lymphocyte ratio plays important roles in carotid stenosis in patients with ischemic stroke and is an independent risk factor of the severity of carotid stenosis. Therefore, MLR might be considered a potential index in the diagnosis of carotid stenosis in patients with ischemic stroke.
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