Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

6.0K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
6.0K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.3K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.3K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

8.9K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
8.9K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.1K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.1K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

800
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
800

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the Genetic and Immunophenotypic Landscape of Chronic Lymphocytic Leukemia in Indian Cohort.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2026
Same author

Structural and functional characterization of mycobacterial PhoH2 and identification of potential inhibitor of its enzymatic activity.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]·2024
Same author

Decoding the structural integrity and multifunctional role of Era protein in the survival of <i>Mycobacterium tuberculosis</i> H<sub>37</sub>Rv.

Journal of biomolecular structure & dynamics·2024
Same author

Elucidating the structural and functional prophecy of the Rv2326c gene, an ABC transporter of Mycobacterium tuberculosis H37Rv through computational approach.

Biotechnology and applied biochemistry·2023
Same author

Development of peptide vaccine candidate using highly antigenic PE-PGRS family proteins to stimulate the host immune response against <i>Mycobacterium tuberculosis</i> H<sub>37</sub>Rv: an immuno-informatics approach.

Journal of biomolecular structure & dynamics·2022
Same author

A multifactorial assessment of the SRP pathway constituent FtsY as a vital mycobacterial constituent.

Biotechnology and applied biochemistry·2021

Related Experiment Video

Updated: Jan 6, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

865

Adhesion molecules facilitate host-pathogen interaction & mediate Mycobacterium tuberculosis pathogenesis.

Durga Bisht1, Laxman S Meena1

  • 1Allergy & Infectious Diseases, CSIR-Institute of Genomics & Integrative Biology, Delhi, India.

The Indian Journal of Medical Research
|October 2, 2019
PubMed
Summary

Mycobacterium adhesion molecules mediate host cell binding and invasion, influencing immune responses and pathogen persistence. Understanding these interactions is key to combating mycobacterial infections.

Keywords:
AdhesionMycobacterium tuberculosisfibronectinfibronectin-binding proteinlipoarabinomannanmacrophagesproline glutamic polymorphic CG repetitive sequence

More Related Videos

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

954
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.2K

Related Experiment Videos

Last Updated: Jan 6, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

865
Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

954
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.2K

Area of Science:

  • Microbiology
  • Immunology
  • Cell Biology

Background:

  • Microorganisms utilize surface adhesion molecules for host cell interaction during infection.
  • Adhesion molecules are crucial for mycobacteria to colonize, invade the host immune system, and trigger host responses.

Purpose of the Study:

  • To review the role of adhesion molecules and their receptors in mycobacterial infections.
  • To elucidate the mechanisms of adhesion molecule-receptor binding and its impact on mycobacterial invasion and persistence.

Main Methods:

  • Literature review focusing on adhesion molecules in mycobacterial pathogenesis.
  • Analysis of signaling pathways and host-pathogen interactions mediated by adhesion molecules.

Main Results:

  • Adhesion molecules facilitate mycobacterial binding to specific host cell receptors.
  • These interactions are critical for mycobacterial invasion and survival within the host.

Conclusions:

  • Understanding adhesion molecule mechanisms provides insights into mycobacterial survival strategies.
  • Targeting these molecules could offer new therapeutic approaches against mycobacterial diseases.