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Management Strategies for POSEIDON Groups 3 and 4.
Thor Haahr1,2, Carlos Dosouto3,4, Carlo Alviggi5,6
1Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Frontiers in Endocrinology
|October 2, 2019
Summary
Patients with poor ovarian reserve (POSEIDON groups 3 and 4) face high risks in assisted reproductive technology (ART). Individualized strategies are crucial for optimizing outcomes and achieving at least one euploid blastocyst for transfer.
Area of Science:
- Reproductive Medicine
- Infertility Research
- Assisted Reproductive Technology (ART)
Background:
- The POSEIDON classification identifies patients with poor ovarian reserve (groups 3 and 4) who are at high risk for poor reproductive outcomes.
- These groups, particularly group 4, represent a growing proportion of patients undergoing ART, necessitating specialized management.
- Approximately 47% of ART patients fall within POSEIDON groups 1-4, highlighting the prevalence of diminished ovarian reserve.
Purpose of the Study:
- To review current evidence on optimizing ART outcomes for patients classified under POSEIDON groups 3 and 4.
- To emphasize the need for individualized treatment strategies in pre-treatment, ovarian stimulation, adjuvant therapies, and ovulation triggering.
- To explore recent advances aimed at improving reproductive success in patients with poor prognosis.
Main Methods:
- Review of recent scientific literature and clinical evidence pertaining to the management of POSEIDON groups 3 and 4.
- Analysis of strategies for ovarian stimulation, adjuvant treatments, and ovulation induction tailored to poor responders.
- Focus on achieving at least one euploid blastocyst for transfer.
Main Results:
- Patients in POSEIDON groups 3 and 4 require tailored approaches across all stages of ART to improve success rates.
- Individualization of treatment protocols is identified as the key factor for enhancing the probability of a positive reproductive outcome.
- Emerging evidence suggests that recent advancements can positively impact reproductive outcomes for these high-risk patients.
Conclusions:
- Specialized attention to pre-treatment, stimulation, and triggering strategies is essential for POSEIDON groups 3 and 4.
- Personalized ART management is critical for maximizing the chances of obtaining a euploid blastocyst in poor prognosis patients.
- Continued research and evidence are needed, but current advances offer hope for improved fertility treatment outcomes.
Keywords:
ART calculatorBologna criteriaPOSEIDON criteriablastocystcontrolled ovarian stimulationpoor ovarian responsepregnancyMore Related Videos
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