Related Experiment Video
Updated: Jan 6, 2026

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments
Published on: May 9, 2019
Preparation, optimization and in vitro-in vivo evaluation of Shunxin sustained release granules
Yinghuan Dou1, Xuefeng Li1, Yanbin Shi1
1School of Basic Medical Sciences, Lanzhou University, Chengguan District, Donggang West Road No.199, Lanzhou, 730000 China.
Background:
Shunxinzufang decoction is tutors, empirical formula and has been used in Chinese patients of HFpEF for several years. The aim of this study was to make into sustained release granules and select the best formula for the preparation of Shunxin sustained release granules and to evaluate its in vivo and in vitro drug release behavior.
Methods:
Response surface methodology and Center composite design were applied to screen the optimal formula of Shunxin sustained release granules. HPLC was used to detect indicative ingredients-paeoniflorin, calycosin-7-glucoside and ferulic acid in Shunxin sustained release granules. The in vitro sustained release character of indicative ingredients was investigated in simulated digestive fluids. In-vivo process of active components was studied through pharmacokinetics.
Results:
The optimal formula of Shunxin sustained release granules consisted of 35% shunxinzufang extract and 65% HPMC/starch (HPMC/starch ratio = 2:1). Three indicative components can be separated well under selected HPLC conditions. Compared with Shunxinzufang extract, the active components of Shunxin sustained release granules have obvious sustained-release character and improved bioavailability.
Conclusion:
Shunxin sustained release granules has obvious sustained-release character and improved bioavailability.
Related Concept Videos
In Vitro Drug Release Testing: Overview, Development and Validation
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
In Vitro Drug Dissolution: Compendial Testing Models I
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

