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Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral
Ping Yang1, Ye-Mei Tian2, Wen-Xiang Deng2
1Department of Psychiatry, Brains Hospital of Hunan Province, Clinical Medical School, Hunan University of Chinese Medicine, Changsha, Hunan 410007, P.R. China.
Experimental and Therapeutic Medicine
|October 2, 2019
Summary
Sijunzi decoction (SJZD) improved neurobehavioral function and reduced neuronal apoptosis in rats after ischemic stroke. This traditional Chinese medicine protected the brain by preserving the extracellular matrix and reducing cell death.
Area of Science:
- Neuroscience
- Pharmacology
- Traditional Chinese Medicine
Background:
- Ischemic stroke causes neuronal degeneration and apoptosis.
- Anoikis, a form of programmed cell death, contributes to neuronal loss.
- Traditional Chinese Medicine (TCM) offers potential therapeutic strategies for stroke recovery.
Purpose of the Study:
- To investigate the effects of Sijunzi decoction (SJZD) on anoikis in rat brains following cerebral ischemia-reperfusion.
- To evaluate the neuroprotective and anti-apoptotic mechanisms of SJZD.
Main Methods:
- Middle cerebral artery occlusion model in rats.
- Administration of SJZD (low, medium, high doses) and nimodipine.
- Assessment of neurobehavioral scores, blood-brain barrier permeability (Evans blue extravasation), and apoptotic rates (TUNEL staining).
- Immunohistochemical analysis of tissue inhibitor of metalloproteinase 1 (TIMP-1), matrix metalloproteinase 9 (MMP-9), and collagen IV (COL IV).
Main Results:
- SJZD significantly improved neurobehavioral scores and reduced blood-brain barrier permeability in a dose-dependent manner.
- SJZD treatment decreased apoptotic rates and modulated the expression of TIMP-1, MMP-9, and COL IV.
- High-dose SJZD demonstrated superior neuroprotective effects compared to lower doses and nimodipine.
Conclusions:
- SJZD exhibits significant neuroprotective effects against cerebral ischemia-reperfusion injury in rats.
- The therapeutic mechanism of SJZD involves the protection of the extracellular matrix and subsequent anti-apoptotic effects.
- SJZD represents a promising therapeutic agent for managing ischemic stroke, particularly at higher doses.
