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In Vitro Transcribed RNA-based Luciferase Reporter Assay to Study Translation Regulation in Poxvirus-infected Cells
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Protein Kinases at the Intersection of Translation and Virulence

Jay Leipheimer1, Amanda L M Bloom1, John C Panepinto1

  • 1Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States.

Frontiers in Cellular and Infection Microbiology
|October 2, 2019
PubMed

Insights

Pathogenic fungi use kinases to control protein translation, enabling virulence in challenging environments. This review explores how these kinases help fungi survive and cause disease.

Area of Science:

  • Mycology
  • Molecular Biology
  • Pathogenesis

Background:

  • Fungi, as free-living organisms, face environmental stresses that can mimic host conditions.
  • These stresses necessitate the production of stress effector proteins and maintenance of viability factors.
  • Kinases play a crucial role in regulating protein translation to balance these demands.

Purpose of the Study:

  • To review the role of kinases in pathogenic fungi.
  • To explore how kinases facilitate virulence through translational control.
  • To understand the mechanisms fungi employ to adapt to environmental challenges.

Main Methods:

  • Literature review of studies on fungal kinases and virulence.
  • Analysis of research on translational control mechanisms in fungi.
  • Focus on kinases that influence protein synthesis and virulence phenotypes.

Main Results:

  • Kinases are central regulators of fungal stress response and adaptation.
  • Translational control by kinases is a key factor in fungal virulence.
  • Specific kinases influence the selection and expression of virulence factors.

Conclusions:

  • Kinases are critical for pathogenic fungi to adapt to environmental insults.
  • Targeting fungal kinases offers potential strategies for controlling fungal infections.
  • Understanding translational control is vital for deciphering fungal pathogenesis.
Keywords:
fungiheat shockkinaseoxidative stressstarvation adaptationstress responsetranslationtranslational regulation

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