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Updated: Jan 6, 2026
Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
[Modern approaches to predicting the development of active type 1 retinopathy of prematurity]
M S Petrachkova1, E I Saidasheva1, D V Petrachkov2
1North-Western State Medical University named after I.I. Mechnikov, 41 Kirochnaya St., Saint Petersburg, Russian Federation, 191015.
Purpose:
To develop a mathematical model for predicting the development of threshold stages (type 1) of active retinopathy of prematurity (ROP) based on neonatal risk factors in premature infants.
Material And Methods:
The study observed 69 premature infants from a perinatal center with gestation age of 22-31 weeks and birth weight of 499-1500 grams. Patients were divided into 2 groups depending on the type of ROP: the main group - 40 infants with a threshold stage (type 1) of ROP, requiring laser treatment; the control group - 29 children with spontaneous regression of the initial (1-2) stages (type 2) of the disease. A model for predicting the development of ROP threshold stage was built using mathematical justification.
Results:
The study established potential predictors of type 1 ROP: staying in the intensive care unit for more than 30 days (p=0.011); duration of child's staying on mechanical ventilator more than 30 days (p=0.002); parenteral nutrition for more than 13 days (p=0.013); presence of respiratory distress syndrome of 3rd degree (p<0.001); presence of bronchopulmonary dysplasia (p=0.034). These predictors were used to design a mathematical model for predicting the development of threshold stages of ROP.
Conclusion:
The proposed prognostic model of type 1 active ROP is characterized by high information content and can be recommended for use in clinical practice of neonatal medical institutions.
