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Why knowing healthy controls matters
1National Institute of Mental Health, Office of the Clinical Director, Bethesda, MD, USA.
Abstract:
Although healthy volunteers often serve as controls or primary participants in neuroscience research, they are usually less rigorously screened than patients, which can have far-reaching implications for interpretation of study results. Although this issue has long been recognised, it is rarely discussed in the research literature. This article examines how the rigorous screening and characterisation of healthy volunteers is key for quality research.
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