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Related Experiment Video

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Central network changes in patients with advanced monocular blindness: A voxel-based morphometric study.

Wen-Qing Shi1, Yin He1, Qing-Hai Li1

  • 1Department of Ophthalmology, Jiangxi Province Ocular Disease Clinical Research Center, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Brain and Behavior
|October 2, 2019
PubMed
Summary

Patients with advanced monocular blindness (MB) experience gray matter volume (GMV) changes in specific brain regions. Reduced GMV correlates with blindness duration, suggesting neuropathological mechanisms in visual loss.

Keywords:
fMRImonocular blindnessvisual functional neuroimagingvoxel-based morphometry

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Clinical Neurology

Background:

  • Monocular blindness (MB) can lead to structural brain changes.
  • Understanding these changes is crucial for diagnosing and managing visual impairment.

Purpose of the Study:

  • To investigate gray matter volume (GMV) alterations in patients with advanced monocular blindness (MB).
  • To explore the relationship between GMV changes and the duration of blindness.

Main Methods:

  • Voxel-based morphometry (VBM) was employed to analyze brain structure.
  • Thirty-one patients with advanced MB and 31 controls were compared.
  • Statistical analyses included t-tests, correlation, and regression analyses.

Main Results:

  • MB patients exhibited decreased GMV in the bilateral insular cortex, right cingulate gyrus, left occipital gyrus, and right suboccipital lobe.
  • GMV reduction in certain areas was negatively correlated with the duration of blindness.
  • Abnormal white matter volume (WMV) and GMV were observed in MB patients.

Conclusions:

  • Advanced monocular blindness is associated with significant GMV and WMV abnormalities.
  • The duration of blindness impacts GMV, suggesting progressive neuropathological changes.
  • These findings highlight potential mechanisms underlying visual loss in MB.