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Keratoconus Could Be Associated With Psoriasis: Novel Findings From a Comparative Study
Hanife Tuba Akcam1, Ebru Karagun2, Ilter Iritas1
1Departments of Ophthalmology and.
Cornea
|October 2, 2019
Summary
Psoriasis patients show increased vertical asymmetry in corneal topography, suggesting a potential link to keratoconus (KC). Early onset and longer disease duration correlate with these topometric changes.
Area of Science:
- Ophthalmology
- Dermatology
- Corneal Ectasias
Background:
- Psoriasis is a chronic inflammatory condition.
- Keratoconus (KC) is a progressive corneal ectasia.
- The relationship between psoriasis and KC requires further investigation.
Purpose of the Study:
- To investigate the potential association between psoriasis and keratoconus (KC).
- To compare corneal topography parameters between patients with psoriasis and healthy controls.
Main Methods:
- Corneal topography was performed on 55 patients with psoriasis and 55 healthy controls.
- Psoriasis Area and Severity Index (PASI) scores were assessed.
- Statistical analysis included chi-square, Mann-Whitney U, and Pearson correlation tests.
Main Results:
- Patients with psoriasis exhibited significantly higher vertical asymmetry in corneal topography compared to controls.
- A notable percentage of psoriatic eyes showed signs suggestive of KC.
- Topometric changes correlated positively with disease duration and PASI score, and negatively with early disease onset.
Conclusions:
- Psoriatic patients may experience significant corneal topography alterations.
- These changes are more pronounced with higher PASI scores and earlier, longer-lasting psoriasis.
- The findings suggest a potential link between psoriasis and the development of KC.
