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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
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Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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Lymphomas and Their Microenvironment: A Multifaceted Relationship.

Thomas Menter1, Alexandar Tzankov2

  • 1Institute of Medical Genetics and Pathology, University of Basel Hospital, Basel, Switzerland.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
|October 2, 2019
PubMed
Summary
This summary is machine-generated.

The tumor microenvironment, including immune cells and structural components, is crucial for cancer growth and survival, especially in lymphomas. Targeting this microenvironment offers new therapeutic strategies for lymphomas.

Keywords:
CytokinesLymphomasMacrophagesMicroenvironmentT-cells

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • The tumor microenvironment (TME) significantly influences cancer progression, including lymphomas.
  • It comprises various cells (lymphocytes, macrophages, fibroblasts), extracellular matrix, and signaling molecules.
  • Understanding TME interactions is vital for developing effective cancer therapies.

Purpose of the Study:

  • To review the critical role of the microenvironment in general tumor growth and specifically in lymphomas.
  • To elucidate the multifaceted interactions between lymphoma cells and their surrounding microenvironment.
  • To highlight the microenvironment as a therapeutic target, focusing on immunomodulatory substances.

Main Methods:

  • Literature review focusing on tumor-microenvironment interactions.
  • Analysis of general principles of tumor-microenvironment interplay.
  • Detailed examination of TME variations across different lymphoma types.

Main Results:

  • Lymphoma cells depend on microenvironmental factors for growth and survival.
  • Lymphomas often suppress the immune system, favoring immunosuppressive cells like M2 macrophages and regulatory T-cells.
  • Diverse TME interactions exist across various lymphoma subtypes.

Conclusions:

  • The tumor microenvironment is integral to lymphoma development and progression.
  • Targeting the microenvironment, particularly immunomodulatory aspects, presents a promising therapeutic avenue for lymphomas.