Related Experiment Video

Updated: Jan 6, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

14.8K

Water-Filled Vesicles of Choroid Plexus Tumors

Mehmet Dumlu Aydin1, Ayhan Kanat2, Nuh Cagri Karaavci3

  • 1Ataturk University Medical Faculty Department of Neurosurgery, Erzurum.

The Journal of Craniofacial Surgery
|October 3, 2019
PubMed

Insights

Choroid plexus cysts can cause hydrocephalus through cerebrospinal fluid (CSF) overproduction or blockage. This study highlights the importance of investigating water-filled vesicles in these cases.

Area of Science:

  • Neuroscience
  • Pediatric Neurosurgery
  • Cerebrospinal Fluid Dynamics

Background:

  • Choroid plexus cysts are common neuroepithelial cysts.
  • Hydrocephalus is a condition characterized by excess cerebrospinal fluid (CSF) accumulation in the brain.

Observation:

  • Two cases of hydrocephalus associated with choroid plexus cysts are presented.
  • Case 1: A 1-year-old child with hydrocephalus treated via endoscopic fenestration of choroid plexus cysts.
  • Case 2: A 63-year-old male with a tumor obstructing the aqueduct of Sylvius, impacting the choroid plexus.

Findings:

  • Histological examination revealed choroid epithelium and water-filled vesicles in the cyst wall.
  • The first case demonstrated CSF overproduction due to water-filled vesicles.
  • The second case indicated hydrocephalus caused by tumor-induced blockage of CSF pathways, not CSF overproduction.

Implications:

  • This study reports novel cases of hydrocephalus linked to water-filled vesicles within choroid plexus cysts.
  • Findings underscore the necessity of examining water-filled vesicles in patients with hydrocephalus and choroid plexus abnormalities.
  • Understanding the varied mechanisms of hydrocephalus in these cases can inform treatment strategies.
Abstract

More Related Videos

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus06:45

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus

Published on: December 16, 2022

5.3K
Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies04:25

Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies

Published on: December 15, 2023

3.7K

Related Concept Videos

Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
7.7K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
3.0K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
4.6K
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.9K
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
5.0K
Pinocytosis00:38

Pinocytosis

Cells use energy-requiring bulk transport mechanisms to transfer large particles or large numbers of small particles into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
Pinocytosis ("cellular drinking") is one of three main types of...
4.1K