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Circulating miR-21 levels in hypertensive patients with asymptomatic organ damage

Erkan Yildirim1, Emrah Ermis1, Samir Allahverdiyev1

  • 1Department of Cardiology.

Medicine
|October 3, 2019
PubMed

Insights

Hypertension (HT) can cause asymptomatic organ damage (AOD). This study found that plasma microRNA-21 (miR-21) levels were higher in hypertensive patients with AOD, suggesting miR-21 may indicate organ damage.

Area of Science:

  • Cardiovascular Disease Research
  • Biomarker Discovery
  • Molecular Cardiology

Background:

  • Hypertension (HT) is a major cardiovascular disease risk factor.
  • Asymptomatic organ damage (AOD) is a critical complication of HT.
  • Early detection of AOD is crucial for managing HT.

Purpose of the Study:

  • To compare plasma microRNA-21 (miR-21) levels and AOD markers (carotid intima-media thickness [CIMT], microalbuminuria [MAU]) between hypertensive patients and healthy controls.
  • To evaluate plasma miR-21 levels in hypertensive patients with and without AOD.
  • To explore the relationship between plasma miR-21 and indicators of organ damage in HT.

Main Methods:

  • Cross-sectional observational study design.
  • Inclusion of 32 hypertensive patients and 32 healthy controls.
  • Measurement of plasma miR-21, CIMT, MAU, and C-reactive protein.

Main Results:

  • Plasma miR-21 levels were significantly correlated with systolic and diastolic blood pressure, MAU, C-reactive protein, and CIMT.
  • Hypertensive patients with AOD exhibited significantly higher levels of CIMT, miR-21, and MAU compared to those without AOD.
  • Elevated plasma miR-21 levels were observed in hypertensive patients with AOD.

Conclusions:

  • Plasma miR-21 is a potential biomarker for detecting asymptomatic organ damage in hypertensive patients.
  • Increased miR-21 levels are associated with established markers of organ damage in hypertension.
  • Further research is warranted to elucidate the role of miR-21 in HT-related cardiovascular complications.

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