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NURR1 Impairment in Multiple Sclerosis
Francesca Montarolo1,2, Serena Martire3,4, Simona Perga5,6
1Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Orbassano, 10043 Turin, Italy. francesca.montarolo@unito.it.
International Journal of Molecular Sciences
|October 3, 2019
Summary
The transcription factor NURR1 counteracts inflammation in autoimmune diseases and brain disorders. This review examines NURR1
Area of Science:
- Neuroimmunology
- Molecular Biology
- Endocrinology
Background:
- NURR1 (NR4A) is a transcription factor involved in inflammation and neurodevelopment.
- Altered NURR1 expression is observed in autoimmune diseases, despite no direct genetic association from GWAS.
- NURR1 plays a role in dopamine-associated disorders like Parkinson's disease.
Purpose of the Study:
- To review evidence linking NURR1 to multiple sclerosis (MS).
- To clarify the debated role of NURR1 in this chronic CNS inflammatory autoimmune disease.
Main Methods:
- Analysis of human and murine model studies on NURR1 and MS.
- Review of existing literature on NURR1's anti-inflammatory and neurodevelopmental functions.
Main Results:
- NURR1 exhibits anti-inflammatory properties by inhibiting pro-inflammatory pathways in the CNS and periphery.
- NURR1 is crucial for the development and maintenance of midbrain dopaminergic neurons.
- Evidence suggests NURR1's involvement in neuroinflammatory processes relevant to MS.
Conclusions:
- NURR1's anti-inflammatory actions and role in CNS cells are significant for understanding MS pathogenesis.
- Further research is needed to fully elucidate NURR1's specific contribution to multiple sclerosis.
- Investigating NURR1 may offer therapeutic insights for neuroinflammatory and autoimmune conditions.
