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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Related Experiment Video

Updated: Jan 6, 2026

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
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The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

546

Anti-Inflammatory Diets and Fatigue.

Ulrike Haß1,2, Catrin Herpich3,4, Kristina Norman5,6,7

  • 1Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. uhass@uni-potsdam.de.

Nutrients
|October 3, 2019
PubMed
Summary

Anti-inflammatory diets may help reduce chronic disease-related fatigue by improving inflammatory markers. While single nutrients show limited effects, whole foods like fiber-rich grains, vegetables, and omega-3s show promise for fatigue reduction.

Keywords:
anti-inflammatory nutritioncancerchronic fatiguecytokinesfatigue reduction dietinflammationmyalgic encephalomyelitisomega-3 fatty acidspolyphenolsprobiotics

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Area of Science:

  • Nutrition Science
  • Immunology
  • Chronic Disease Management

Background:

  • Chronic diseases are often associated with a pro-inflammatory state.
  • This inflammation is linked to the development of persistent fatigue.
  • The potential for dietary interventions to modify inflammation and fatigue is an area of active research.

Purpose of the Study:

  • To review the scientific literature on the impact of anti-inflammatory diets on inflammatory markers and fatigue.
  • To assess the effectiveness of anti-inflammatory nutrients, foods, and dietary patterns in managing fatigue across different patient groups.

Main Methods:

  • A narrative review of observational, epidemiological, and clinical studies.
  • Evaluation of 21 human trials investigating anti-inflammatory interventions.
  • Analysis of effects on inflammatory biomarkers and self-reported fatigue levels.

Main Results:

  • Evidence for single anti-inflammatory nutrients significantly reducing fatigue is currently limited and indicative.
  • Clinical studies suggest that balanced diets rich in whole grains, fiber, polyphenols, and omega-3 fatty acids may improve fatigue symptoms.
  • Conflicting results exist, necessitating further investigation.

Conclusions:

  • Dietary patterns, rather than isolated nutrients, appear more promising for managing chronic disease-related fatigue.
  • Whole foods rich in fiber, polyphenols, and omega-3s show potential for fatigue symptom improvement.
  • Further high-quality human trials are required to confirm these findings and resolve inconsistencies in the current literature.