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Within subject variability of HDL-cholesterol in HIV-infected patients
Bernardino Roca1, Maria Alexandra Mendoza1, Manuel Roca1
1Department of Health of Castellon, University of Valencia, Valencia, Spain.
Insights
High-density lipoprotein cholesterol (HDL-C) levels vary significantly in people with HIV. Smoking is linked to less HDL-C variability, suggesting a potential impact on cardiovascular disease risk.
Area of Science:
- Cardiology
- Infectious Diseases
- Biochemistry
Background:
- Cardiovascular disease (CVD) risk factors exhibit within-subject variability, potentially impacting disease development.
- HIV-infected individuals face elevated CVD risk, necessitating a deeper understanding of their specific risk factors.
- High-density lipoprotein cholesterol (HDL-cholesterol) variability's clinical significance in HIV patients requires further investigation.
Purpose of the Study:
- To quantify HDL-cholesterol variability between two consecutive visits in HIV-infected patients.
- To identify factors associated with HDL-cholesterol variability in this high-risk population.
- To enhance understanding of HDL-cholesterol's clinical significance in the context of HIV infection.
Main Methods:
- Cohort study design.
- Inclusion of 307 HIV-infected patients.
- Quantification of HDL-cholesterol variability using absolute differences between two visits.
Main Results:
- Mean age of participants was 45.1 ± 8.5 years, with 73.3% being male.
- The mean absolute difference in serum HDL-cholesterol was 12.1 ± 9.2 mg/dL.
- Smoking was significantly and inversely correlated with HDL-cholesterol variability (P = 0.009).
Conclusions:
- Substantial within-subject variability of HDL-cholesterol exists among HIV-infected patients.
- Smoking cessation or reduction may influence HDL-cholesterol stability in HIV patients.
- Understanding HDL-cholesterol variability is crucial for managing cardiovascular risk in HIV-infected individuals.
Abstract:
Background and objective: Within-subject variability of cardiovascular risk factors may influence the development of cardiovascular disease. We aimed to improve knowledge on HDL-cholesterol variability and its clinical significance in HIV-infected patients, a population at high risk of cardiovascular disease.Methods: This was a cohort study to quantify the variability of HDL-cholesterol between two consecutive visits and to determine factors associated with such variability, in a group of HIV-infected patients.Results: A total of 307 patients were included, mean ± standard deviation of their age was 45.1 ± 8.5 years, and 225 of them (73.3%) were male. The absolute difference (after squaring and root squaring) of serum HDL-cholesterol level between the first and the second visit was 12.1 ± 9.2 mg/dL. In 65 patients (21.2%) the absolute value of the difference between both serum HDL-cholesterol level results were 20 mg/dL or higher. In a multivariable analysis the number of cigarettes smoked per day showed a significant, negative, correlation with the absolute difference in serum HDL-cholesterol level between the two visits (P = 0,009).Conclusions: Within-subject variability of HDL-cholesterol was substantial among our HIV-infected patients. Smoking was inversely correlated with such variability.
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