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Related Experiment Videos

Biocide patch tests.

K E Andersen, N K Veien

    Contact Dermatitis
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study found limited usefulness in a standard patch test battery for industrial biocides, with unexplained positive reactions observed in some dermatitis patients. Variations in patient demographics across clinics suggest differing referral patterns or environmental factors.

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    Area of Science:

    • Dermatology
    • Allergology
    • Toxicology

    Background:

    • Industrial biocides are common in consumer products.
    • Patch testing is crucial for diagnosing contact dermatitis.
    • Evaluating standardized test batteries is essential for clinical practice.

    Purpose of the Study:

    • To assess the clinical utility of a patch test series of six industrial biocides.
    • To correlate patch test results with guinea pig allergy test data.
    • To analyze demographic and clinical variations among patients across different clinics.

    Main Methods:

    • Patch testing 1652 dermatitis patients with six industrial biocides: methylene-bis-thiocyanate (Cytox 3522), benzisothiazolin-3-one (BIT), chlorocresol (Preventol CMK), 2-n-octyl-4-isothiazolin-3-one (Kathon 893), polyhydroxymethylene monobenzylether (Preventol D2), and 1,3,5-tris (hydroxy-ethyl) hexahydrotriazine (Grotan BK).

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  • Comparison with guinea pig allergy test results.
  • Analysis of the MOAHL-index (Male, Occupational, Atopic, Hand eczema, Leg ulcer/stasis dermatitis) to identify patient population differences.

    • Main Results:

    • The patch test battery demonstrated limited usefulness.
    • A few unexplained positive reactions were noted for Cytox 3522, BIT, Preventol D2, and Grotan BK (formaldehyde releasers).
    • Significant variations in occupational cases, hand eczemas, and leg ulcers/stasis dermatitis were observed across the six clinics.

    Conclusions:

    • The evaluated patch test battery has limited diagnostic value for common industrial biocides.
    • Unexplained positive reactions warrant further investigation.
    • Clinic-specific demographic differences highlight potential variations in referral patterns and environmental exposures.