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Single-Cell RNA Sequencing Reveals a Developmental Hierarchy in Langerhans Cell Histiocytosis

Tanja A Gruber1

  • 1Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee. tanja.gruber@stjude.org.

Cancer Discovery
|October 3, 2019
PubMed

In this issue of Cancer Discovery, Halbritter and colleagues utilize single-cell RNA sequencing to dissect the cellular hierarchy in Langerhans cell histiocytosis. They identified a remarkably consistent composition of 14 cellular subsets across all patients with a range of clinical spectrums consistent with a shared developmental hierarchy driven by key transcriptional regulators.See related article by Halbritter et al., p. 1406.

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