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Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo

Amber L Fifield1, Paul D Hanavan2, Douglas O Faigel3

  • 1School of Life Sciences, Arizona State University, Tempe, Arizona.

Molecular Cancer Therapeutics
|October 3, 2019
PubMed

Insights

A novel inhibitor, SBI-183, targeting Quiescin sulfhydryl oxidase 1 (QSOX1) effectively suppresses tumor growth and invasion. This discovery offers a potential new strategy for treating cancers overexpressing QSOX1.

Area of Science:

  • Biochemistry
  • Oncology
  • Drug Discovery

Background:

  • Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme overexpressed in various tumor types.
  • QSOX1's role in catalyzing disulfide bond formation is implicated in tumor growth and invasion.

Purpose of the Study:

  • To investigate QSOX1 inhibitors as potential anticancer agents.
  • To evaluate the efficacy of SBI-183 in preclinical cancer models.

Main Methods:

  • High-throughput screening identified QSOX1 inhibitors.
  • SBI-183 tested in spheroid and Boyden chamber assays for tumor cell growth and invasion.
  • SBI-183 evaluated in xenograft mouse models of renal cell carcinoma.

Main Results:

  • SBI-183 suppressed tumor cell growth and invasion without affecting nonmalignant cells.
  • Oral administration of SBI-183 inhibited tumor growth in two distinct xenograft models.
  • SBI-183 demonstrated specific inhibition of QSOX1 enzymatic activity.

Conclusions:

  • SBI-183 is a potent inhibitor of QSOX1 with anticancer properties.
  • SBI-183 shows promise as a novel therapeutic agent for QSOX1-overexpressing tumors.
  • Further research into SBI-183 is warranted for its potential in cancer therapy and QSOX1 biology studies.

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