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Generation of T cell growth factor (TCGF)- dependent splenic lymphoid cell line with cell-mediated immunosuppressive
European Journal of Cancer & Clinical Oncology
|February 1, 1985
Abstract:
Splenic T cells obtained from tumor-bearing mice could be cultured with T cell growth factor (TCGF) for over 12 months. The TCGF-dependent lymphoid cell line strongly inhibited cell-mediated anti-tumor immunity directed against syngeneic tumor. However, the suppression was non-specific for the given tumor. The cell line expanded with TCGF expressed a phenotypic characterization of T cells defined by monoclonal anti-Thy-1.2 antibody.