Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia

Area of Science:

• Integrative medicine
• Rheumatology
• Biochemistry

Background:

• Fibromyalgia (FM) is a chronic condition characterized by widespread pain, fatigue, and cognitive difficulties.
• Current FM management often involves pharmacotherapy with potential side effects.
• Oxidative stress is implicated in the pathophysiology of FM.

Purpose of the Study:

• To evaluate the efficacy of autohemotherapy with ozone in managing fibromyalgia symptoms.
• To assess the impact of ozone therapy on biochemical markers and oxidative stress in FM patients.

Main Methods:

• A study involving 20 FM patients diagnosed by American College of Rheumatology criteria.
• Patients received 10 sessions of ozone autohemotherapy (30-60 mcgr/ml concentration).
• Evaluations included the Fibromyalgia Impact Questionnaire (FIQ), symptom assessment, and analysis of serum serotonin, reactive oxygen species (ROS), lipid peroxidation (LP), and protein carbonyl (PC) levels.

Main Results:

• Patients reported improved sleep, mental alertness, and reduced asthenia (fatigue).
• Significant decreases in FIQ scores and tender points were observed.
• Moderate increases in serotonin levels and notable reductions in LP and PC were recorded, indicating decreased oxidative stress.

Conclusions:

• Ozone autohemotherapy effectively reduces fibromyalgia symptoms and oxidative stress markers.
• This therapy may enhance patients' vitality and reduce reliance on conventional medications, minimizing adverse effects.
• Further large-scale clinical trials are warranted to confirm these findings.