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Red cell enzyme types in rheumatic diseases.

Krylov MYu, V P Gurbanov, V V Makarov

    Human Heredity
    |January 1, 1985
    PubMed
    Summary

    Red cell enzyme frequencies differ in autoimmune diseases. Psoriatic arthropathy showed significant changes in AcP phenotypes and PGM1 enzyme types compared to controls.

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    Area of Science:

    • Immunogenetics
    • Rheumatology
    • Biochemistry

    Background:

    • Red blood cell enzyme polymorphisms are studied for their association with various diseases.
    • Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), rheumatic heart disease (RHD), scleroderma (Scl), and psoriatic arthropathy (PsA) are autoimmune and rheumatic conditions with complex etiologies.
    • Understanding genetic variations may offer insights into disease susceptibility and mechanisms.

    Purpose of the Study:

    • To investigate the frequencies of specific red cell enzyme types, Acid Phosphatase (AcP), Phosphoglucomutase 1 (PGM1), and Esterase D (EsD), in patients diagnosed with RA, SLE, RHD, Scl, and PsA.
    • To compare these frequencies with those observed in the general Moscow population to identify significant associations.

    Main Methods:

    • Analysis of red cell enzyme phenotypes (AcP, PGM1, EsD) in a cohort of 213 patients with rheumatic and autoimmune diseases.
    • Statistical comparison of observed phenotype frequencies against a reference population (Moscow).

    Main Results:

    • Significant differences in the frequencies of Acid Phosphatase (AcP) phenotypes were observed between patients with Rheumatoid Arthritis (RA), Scleroderma (Scl), Psoriatic Arthropathy (PsA), and the general Moscow population.
    • In Psoriatic Arthropathy (PsA) patients, a significant decrease in the PGM1 phenotype 1-1 frequency and a significant increase in the PGM1 phenotype 2-1 frequency were noted.

    Conclusions:

    • The study highlights significant variations in red cell enzyme polymorphisms, specifically AcP and PGM1, among patients with certain rheumatic and autoimmune diseases, particularly PsA.
    • These findings suggest a potential genetic link between these red cell enzyme types and the susceptibility or manifestation of these conditions.

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