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Related Experiment Videos

Hereditary multiple exostoses with myelopathy.

S U Ho, H L Lipton

    Archives of Neurology
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Hereditary multiple exostoses can cause rare central nervous system (CNS) complications, such as spinal cord compression from vertebral exostosis. This case highlights the importance of considering CNS involvement in patients with this condition.

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    Area of Science:

    • Neurology
    • Genetics
    • Orthopedics

    Background:

    • Hereditary multiple exostoses (HME) is a rare genetic disorder characterized by the development of multiple bony outgrowths (exostoses) on bones.
    • Central nervous system (CNS) complications are uncommon in HME, with spinal cord involvement being particularly rare.

    Observation:

    • A 58-year-old woman with HME presented with slowly progressive myelopathy.
    • Imaging revealed a vertebral exostosis compressing the spinal cord at the T1-T2 level.
    • The patient exhibited numerous palpable long-bone exostoses but no overt skeletal deformities.

    Findings:

    • This case represents the 18th reported instance of CNS complications in hereditary multiple exostoses.
    • Vertebral exostosis causing spinal cord compression is a significant, albeit rare, manifestation of HME.

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    Implications:

    • Highlights the potential for neurological deficits in HME patients.
    • Emphasizes the need for vigilance in diagnosing and managing spinal cord compression in HME.
    • Underscores the importance of considering HME in the differential diagnosis of myelopathy, even without typical skeletal features.