Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Amyloid Fibrils03:03

Amyloid Fibrils

6.2K
6.2K
Amyloid Fibrils03:03

Amyloid Fibrils

11.5K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
11.5K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

917
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
917
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel technique for treating extraocular muscle adherence after fracture repair.

The British journal of ophthalmology·2026
Same author

Tumors of the Lacrimal Drainage System: Diagnosis and Management.

Cancers·2026
Same author

Optic Nerve Stretch in Dysthyroid Optic Neuropathy: A Systematic Review and Meta-Analysis.

Ophthalmic plastic and reconstructive surgery·2026
Same author

Orbital metastases from uterine or adrenal leiomyosarcoma: case reports and literature review.

Orbit (Amsterdam, Netherlands)·2026
Same author

Orbital solitary fibrous tumour invading the levator palpebrae and superior rectus muscle complex.

Orbit (Amsterdam, Netherlands)·2026
Same author

Establishing a multidisciplinary one-stop thyroid clinic: an innovative model to expedite thyroid cancer diagnosis and enhance patient-centered care.

International journal of surgery (London, England)·2026

Related Experiment Video

Updated: Jan 6, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K

Ocular amyloid: adnexal and systemic involvement.

Swan Kang1, Mohammad H Dehabadi1, Geoffrey E Rose1,2

  • 1Moorfields Eye Hospital, NHS Foundation Trust, London, UK.

Orbit (Amsterdam, Netherlands)
|October 3, 2019
PubMed
Summary

Ocular adnexal and orbital amyloidosis often presents with delayed diagnosis due to varied symptoms. While rarely sight-threatening, this condition requires biopsy for confirmation and can be linked to systemic diseases.

Keywords:
Adnexalamyloidamyloidosisocularorbital

More Related Videos

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.1K
Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

2.7K

Related Experiment Videos

Last Updated: Jan 6, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.1K
Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

2.7K

Area of Science:

  • Ophthalmology
  • Pathology
  • Oncology

Background:

  • Ocular adnexal and orbital amyloidosis is a rare condition.
  • Diagnosis can be challenging due to non-specific presentations.

Purpose of the Study:

  • To investigate the natural history of ocular adnexal and orbital amyloidosis.
  • To understand the diagnostic challenges and long-term outcomes.

Main Methods:

  • Retrospective case series of patients with biopsy-proven amyloidosis.
  • Data collected from 1980 to 2016.
  • Analysis of clinical records, including presentation, diagnosis, treatment, and follow-up.

Main Results:

  • Forty-one patients were identified, with a mean diagnostic delay of 24 months.
  • Common presentations included conjunctival mass and ptosis.
  • Systemic disease or hematological malignancy was found in 25% of patients.
  • 51% required surgical intervention, and 5% received radiotherapy.

Conclusions:

  • Delayed diagnosis is common due to varied presentations and the need for biopsy.
  • Ocular adnexal and orbital amyloidosis has significant morbidities but is rarely sight-threatening.
  • A systemic association, including hematological malignancy, is present in a quarter of cases.