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Related Concept Videos

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
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Related Experiment Video

Updated: Jan 6, 2026

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
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Platelet Biogenesis in the Lung Circulation.

Emma Lefrançais1, Mark R Looney2

  • 1Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.

Physiology (Bethesda, Md.)
|October 3, 2019
PubMed
Summary
This summary is machine-generated.

Platelet production occurs in the lungs, not just the bone marrow. Megakaryocytes from the bone marrow travel to the lungs and release platelets there.

Keywords:
lungmegakaryocytesplateletsthrombopoiesis

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Area of Science:

  • Hematology
  • Pulmonary Medicine
  • Cell Biology

Background:

  • Megakaryocytes are essential for platelet production.
  • Historical evidence suggested a role for the lungs in platelet generation.
  • The precise location of platelet production has been debated.

Purpose of the Study:

  • To investigate the role of the lungs in platelet production.
  • To determine the origin and location of megakaryocyte-mediated platelet release.

Main Methods:

  • Utilized intravital microscopy techniques.
  • Observed megakaryocyte behavior within the lung circulation.
  • Tracked embolized bone marrow megakaryocytes.

Main Results:

  • Demonstrated that platelet release occurs within the lung.
  • Confirmed that bone marrow megakaryocytes embolize into the lung circulation.
  • Provided direct visualization of platelet production in the lung.

Conclusions:

  • The lungs are a significant site for platelet production.
  • Embolized bone marrow megakaryocytes contribute to lung-based platelet release.
  • Challenges the traditional view of the bone marrow as the sole site of platelet production.