Epileptiform EEG discharges and sevoflurane in children: Protocol of a systematic review and meta-analysis
Mengrong Miao1,2, Yuehua Xu2,3, Xuhui Cong2
1Department of Anesthesia and perioperative medicine, Henan University People's Hospital, Henan Provincial People's Hospital of Henan University.
Insights
This systematic review examines sevoflurane's potential to cause epileptiform discharges in children's EEGs. It aims to clarify the incidence, characteristics, and risk factors of these events during anesthesia.
Area of Science:
- Anesthesiology
- Pediatric Neurology
- Clinical Neurophysiology
Background:
- Epileptiform discharges on electroencephalogram (EEG) are noted during sevoflurane mask induction in children.
- The precise incidence, characteristics, and risk factors of these EEG patterns under sevoflurane anesthesia remain unclear.
- Understanding these effects is crucial for pediatric anesthesia safety.
Purpose of the Study:
- To systematically review the epileptic potential of sevoflurane in pediatric patients.
- To determine the incidence, characteristics, and risk factors of epileptiform discharges during sevoflurane anesthesia.
- To provide evidence-based insights for clinical practice.
Main Methods:
- Systematic literature search of PubMed, EMBASE, and Cochrane Library (Central) up to December 2018.
- Focus on studies monitoring EEG during sevoflurane anesthesia in children.
- Meta-analysis planned using R software for quantitative synthesis.
Main Results:
- This review will provide novel evidence regarding the incidence of EEG epileptic discharges.
- It will detail the specific characteristics of these discharges.
- Risk factors associated with sevoflurane-induced epileptiform activity will be identified.
Conclusions:
- The findings will enhance understanding of sevoflurane's neurological effects in children.
- This systematic review will inform anesthetic management for pediatric patients, including those with epilepsy.
- Results will aid clinicians in mitigating potential risks associated with sevoflurane.
Background:
Epileptiform discharges in electroencephalogram (EEG) have been frequently reported in children undergoing sevoflurane mask induction. However, the incidence, characteristics and risk factors of these epileptiform patterns during sevoflurane anesthesia in children are poorly understood. The aim of this study is to systematically review the epileptic potential of sevoflurane in children with the EEG monitoring.
Methods:
PubMed, EMBASE, Cochrane library (Central) will be systematically searched from inception to December 2018. The effect of sevoflurane on epileptic EEG patters in children will be studied. The primary outcome will be the incidence of epileptic discharges, the characteristics and risk factors of these epileptic discharges. Meta-analysis will be calculated using R software 3.5.1.
Results:
This study will offer new evidence of the incidence, characteristics and risk factors of EEG epileptic discharges during sevoflurane anesthesia.
Conclusion:
The conclusion drawn from this systematic review will benefit the children with or without epilepsy undergoing sevoflurane anesthesia.
Ethics And Dissemination:
Ethics approval is unnecessary because data of individual patients will not be included and no privacy will be involved. The results of this review will be published in a peer-reviewed journal or a conference report. Amendments of the basic protocol will be documented in the comprehensive review.
Prospero Registration Number:
PROSPERO CRD 42019122008.
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