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The association of two common polymorphisms in miRNAs with diabetes mellitus: A meta-analysis

Guixin Li1, Beibei Liu, Qianqian Jiang

  • 1Division of Gastroenterology, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Medicine
|October 3, 2019
PubMed
Abstract

Insights

This meta-analysis found that miRNA27a rs895819 may protect against diabetes, while miRNA146a rs2910164 showed no significant association with diabetes susceptibility. These findings contribute to understanding genetic risk factors for diabetes.

Area of Science:

  • Genetics
  • Molecular Biology
  • Endocrinology

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs implicated in various diseases.
  • Single nucleotide polymorphisms (SNPs) in miRNAs can alter their function and disease association.
  • Diabetes mellitus (DM) is a growing global health concern, with genetic factors playing a role in its susceptibility.

Purpose of the Study:

  • To investigate the association between two common miRNA polymorphisms (miRNA 146a rs2910164 and miRNA 27a rs895819) and diabetes mellitus.
  • To resolve conflicting findings in previous studies regarding these genetic variants and diabetes risk.

Main Methods:

  • A comprehensive meta-analysis was conducted using data from four major scientific databases.
  • Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association.
  • Subgroup analyses (e.g., by ethnicity and diabetes type) and sensitivity analyses were performed to ensure robustness.

Main Results:

  • The meta-analysis included six studies for miRNA 146a rs2910164 (2585 cases, 2435 controls) and five studies for miRNA 27a rs895819 (2922 cases, 2781 controls).
  • No significant association was found between miRNA 146a rs2910164 and diabetes across all genetic models and subgroups.
  • A significant protective association was observed for miRNA 27a rs895819 with diabetes, particularly in the homozygote (CC vs TT) and recessive (CC vs CT+TT) models, and the C allele showed a protective effect in Caucasians.

Conclusions:

  • miRNA 27a rs895819 may confer a protective effect against the development of diabetes.
  • miRNA 146a rs2910164 does not appear to be significantly associated with diabetes risk.
  • These findings highlight the potential role of specific miRNA polymorphisms in diabetes pathogenesis.

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