Related Experiment Video
Updated: Jan 6, 2026

Author Spotlight: High-Throughput Toxicity Screening Using Zebrafish Embryo Startle Response Assay
Published on: January 12, 2024
[National poisoning registers and toxicovigilance in different countries as models for Germany]
1Bundesinstitut für Risikobewertung, Max-Dohrn-Straße 8-10, 10589, Berlin, Deutschland. axel.hahn@bfr.bund.de.
Abstract:
As of 2019, Germany has still not been able to provide a national poisoning register and toxicovigilance for sufficient and reliable information on human exposure for the purpose of identification and assessment of toxic risk to the public. In particular, the USA acts as a special model, but France, the Netherlands, Switzerland, and Sweden also have efficient poisoning registers and toxicovigilance systems that deliver representative human exposure data as early warning systems for risk minimization and prevention. This contribution presents an overview of national poisoning registers and systems of toxicovigilance in different countries and describes the present situation in Germany where, from a public health point of view, insufficient political development in this area has so far been supplied.In Germany, the database for poisoning analysis is still insufficient because poisonings as an important medical entity does not find sufficient medical-statistical correspondence in the ICD Code. Cooperation between the Federal Institute for Risk Assessment (BfR) and the German Poison Centres (GIZ) has already led to significant progress and results in risk minimization, but due to the lack of representative data and the non-implementation of a national monitoring and toxicovigilance system, false estimations of poisoning situations can not be excluded.yIn the future, acute poisoning, and when appropriate chronic poisoning, can be competently assessed via human exposure in the German Poison Centres and through medical reports on poisoning at the BfR. This requires an effective national monitoring and toxicovigilance system supported and financed by government across the borders of the German federal states.
Related Concept Videos
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Regulation
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Prevention of Further Absorption of Poison
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...

