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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Insights into IL-29: Emerging role in inflammatory autoimmune diseases
Jia-Min Wang1, An-Fang Huang2, Wang-Dong Xu1
1Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, Sichuan, China.
Abstract:
Interleukin-29 (IL-29) is a newly discovered member of type III interferon. It mediates signal transduction via binding to its receptor complex and activates downstream signalling pathways, and therefore induces the generation of inflammatory components. Recent studies reported that expression of IL-29 is dysregulated in inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, Sjögren's syndrome, psoriasis and systemic sclerosis. Furthermore, functional analysis revealed that IL-29 may involve in the pathogenesis of the inflammatory autoimmune disorders. In this review, we will systematically review the current knowledge about IL-29. The information collected revealed the regulatory role of IL-29 and may give important implications for its potential in clinical treatment.
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